In this research, the prediction cognitive flexibility obtained by general self-efficacy, academic self-efficacy, social self-efficacy, emotional self-efficacy and achievement is examined. This study is executed in 2014-2015 academic year on 760 high school students who are between ages 15 and 18. Cognitive flexibility Scale is developed by Bilgin (2009b) is used for defining cognitive flexibility, Self-Efficacy Scale is developed by Çelikkaleli, Gündogdu ve Kiran-Esen (2006) is used for defining self-efficacy. Achievement information are determined from TEOG's input points of students. Data are tested by regression analysis. The results of research shows the facts that cognitive flexibility is predicted meaningfully in positive direction by five of the variables "achievement, general self-efficacy, academic self-efficacy, social self-efficacy and emotional self-efficacy." In the multiple regression analysis, it is found that five variables all together explain 34% of cognitive flexibility. Also, it is found in stepwise regression analysis that cognitive flexibility is predicted meaningfully by their two variables.