Background: Hypothyroidism is associated with dyslipidemia. The present study was conducted to assess the relation between hypothyroidism and lipid parameters and lipid ratios. It is also done to assess the severity of hypothyroidism on lipid parameters. Methods: Study comprises of 120 participants were divided into four groups depending on TSH levels, each group comprising of 30 participants. Group-1 euthyroid as controls, group-2 hypothyroid patients with TSH levels between 6-20 IU/mL, group-3 TSH levels between 21-50 IU/mL and group-4 consists of hypothyroid patients with TSH levels of > 50 IU/mL. Fasting venous blood was collected from all the participants and analysed for estimation of thyroid profile and lipid profile. Lipid ratios were calculated. Results: There was significant (p < 0.05) increase in total cholesterol, triglycerides, LDL-C and HDL-C in all the groups compared to group-1 i.e controls. There was significant increase (p<0.05) in lipid ratios. There is positive correlation between TSH and lipid parameters. Conclusion: Our study shows hypothyroid patients show dyslipidemia and the effect of hypothyroidism on lipid parameters is more marked in patients with higher serum TSH levels. By calculating the lipid ratios from lipid parameters are better indicators of dyslipidemia and cardiovascular risk in hypothyroid patients.

Objective: To study the effects of subclinical and overt hypothyroidism on serum levels of low density lipoprotein(LDL), total cholesterol(TC), high density lipoprotein (HDL) and triglycerides(TG). And also to compare the results with normal healthy individuals and with previously published reference data. Lipid profile was estimated in 119 cases of subclinical hypothyroidism and 46 cases of overt hypothyroidism patients attending OPD of a major tertiary health care centre in Punjab. Method: The study was done in the department of Biochemistry, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar. The serum TSH, FT3, FT4 was done by enhanced chemiluminescence technique using vitros Eci-ortho Clinical Diagnostics and lipid profile on semi autoanalyser. The cases were divided into two groups after studying the thyroid profile i.e. subclinical hypothyroidism characterized by elevated serum TSH with normal FT4 and overt hypothyroidism characterized elevated TSH with low...

Background: It well is known that thyroid hormones are involved in regulation of lipid and lipoprotein metabolism; therefore, thyroid dysfunctions induce a significant change in lipid levels. Thyroid hormones are an important modulator of intermediary metabolism. Objectives: This study was conducted to observe the correlation between hypothyroidism, hyperthyroidism and lipid profile in thyroid dysfunction patients. Methods: The study group consists of 118 subjects of both sex (53 males & 65 females) between the age 20-87. The samples of these patients were collected from Asian Institute of Medical Science at Faridabad region. The subjects were divided into four groups the first group consisting 51 subjects for hypothyroidism which also divided into two subgroups 14 patients suffering from overt hypothyroidism and 37 patients suffer from sub-clinical hypothyroidism, second group for normal conditions or control which consist 20 subjects, third group consisting 14 patients suffering from hyperthyroidism, and last group consist 33 patient suffer cardiac disease. About 3 ml blood samples were collected to detect FT3, FT4, TSH, cholesterol, triglyceride, HDL-C, LDL-C, and VLDL-C analyzed in the lab of Asian Institute of Medical Science in Faridabad region. Results: The present study demonstrated multiple biochemical abnormalities in the serum lipids in hypothyroidism and hyperthyroidism subjects, there is an increase in the most lipid profile in both hypothyroid and hyperthyroid patients, and finally, dyslipidemia which is one of the major risk factors of atherosclerosis and coronary disease. There is an increase in total cholesterol, VLDL-C, and levels and decreased in HDL-C in hypothyroidism patients. And there is also increase in total and LDL cholesterol, and decreased in HDL-C level in hyperthyroidism patients, within no changes in VLDL and levels, and there is no significant between hypothyroidism and hyperthyroidism groups). Conclusion: This study concluded that there is an increase in the most lipid profile in both hypothyroid and hyperthyroid patients and finally dyslipidemia which is one of the major risk factors for atherosclerosis and coronary disease. There is an increase in total cholesterol, VLDL-C, and levels and decreased in HDL-C in hypothyroidism patients. And there is also increase in total and LDL cholesterol, and decreased in HDL-C level in hyperthyroidism patients.

Assocation between hypothyroidism and lipid profile has been focussed in this study. This is an observational study. Lipid profile in 200 patients of hypothyroidism has been studied in this study. Chemiluminescence (CLIA) Method was used to estimate levels ofT3,T4,TSH quantitatively serum was estimated on the fully automated biochemistry analyser using the analyser specific Roche kit for total serum cholesterol, HDL cholesterol, and triglycerides. Friedwalds formula was used to calculate LDL cholesterol.Out of 200 patients 135 were of subclinical hypothyroidism and 65 belong to overt hypothyroidism. Females had higher prevalence consisting of 85% of cases.

Objective: It has been known that overt hypothyroidism is associated with hyperlipidemia, replacement therapy with Levothyroxine significantly reverses lipid metabolism abnormalities. But no clear consensus has been established regarding the treatment of Subclinical Hypothyroidism subjects. This is due to the fact that there are no data from large trials on whether and to what degree Subclinical Hypothyroidism affects lipid profile. This study is aimed to provide a look at the status of Lipid Profile in the case of Subclinical Hypothyroidism. Materials and Methods: Total 100 subjects were recruited and divided into 2 groups. 50 Patients with Subclinical Hypothyroidism were considered as the cases and 50 healthy people as the controls. Serum TSH was analysed by sandwich electrochemiluminescence immunoassay method. Serum cholesterol, triglyceride and HDL were estimated by enzymatic colorimetric method, LDL was calculated by using friedewald formula. Results: Serum cholesterol, LDL were higher (P<0.0001) and HDL (P<0.0001) was lower in Subclinical Hypothyroid patients (mean±SD= 199.9±27.8 mg/dl, 130.0±26.3mg/dl, 44.2±9.1 mg/dl respectively) compared to healthy controls (mean±SD= 170.1±16.8 mg/dl, 97.3±14.7 mg/dl, 54.2±10.0 mg/dl respectively). A significant correlation was found between the levels of TSH and Serum Cholesterol (r=0.5101, P<0.0001), LDL (r=0.5637, P<0.0001) and a significant negative correlation was found between the levels of TSH and HDL (r=-0.4525, P<0.0001). Conclusion: Subclinical hypothyroidism is associated with elevated levels of Serum Total Cholesterol and LDL which is atherogenic in nature, and low level of HDL. This may further increase the risk of development of atherosclerosis.

Background: Thyroid disorders are more prevalent in women, and can cause many problems including weight gain and hormonal imbalance. Hypothyroidism is related with various biochemical changes. Increased levels of TC(Total Cholesterol) and LDL(Low Density Lipoproteins) are seen when thyroid function decreases. So, we designed the study to evaluate patients of Thyroid dysfunction and its effects on the lipid profile. Material & Methods: A Case Control Study was conducted on Patients with thyroid disorder attending both OPD and IPD in Department of Medicine in MGMCH, Jaipur, Rajasthan during December 2015 to December 2016. A total of 80 Subjects, 40 subjects with thyroid disorder and 40 euthyroid controls were included in the study. Presence of thyroid dysfunction is defined as per American Thyroid Association Guidelines. Results: Our results showed that the mean age of patients was 38 years, with a female preponderance over males in our study. The mean BMI in the cases was 24.04±2.821 kg/m 2 when compared to 23.18±2.333 kg/m 2 in controls; but it was not statistically significant (P=0.1432) (table 1). The mean value of TSH, Total T3 & Total T4 was statistically significant (P<0.0001***, P=0.0289* & P=0.0116* respectively). The significant rise of serum cholesterol, LDL, VLDL & TG but without increased HDL levels were observed in hypothyroid patients. Conclusion: We concluded that the thyroid abnormalities were more common in the elderly female patients. Total Cholesterol, LDL, VLDL and Triglycerides were observed to rise with declining thyroid function and rising TSH levels. Cases of subclinical hypothyroidism could also be identified on the basis of high TSH levels in the face of normal T3, T4 values.

Background : Subclinical hypothyroidism could damage vascular function by suggesting enhance in SVR and arterial rigidity and by changing endothelial purpose and so increasing the danger of atherosclerosis and coronary artery disease. The objective of this study is to analyze the relation amid SCH and serum lipid parameters in this subgroup. Subjects and Methods: Current research was performed for the duration of one year at the Department of Medicine, tertiary care institute of India, in patients diagnosed with Sub Clinical Hypothyroidism. Eighty patients were incorporated in the present study and 80 age- and sex-matched and regularly menstruating healthy controls, which were evaluated for the Thyroid Function test, were randomly recruited from staff and volunteers. T3, T4, and TSH were anticipated by utilizing quantitative hard stage ELISA, whereas TC was estimated with photometric determination according to the CHOD PAP method; TG and HDL were estimated by using the enzymatic col...